Use of Spray Dried Microspheres Technique to Enhance Solubility of Poorly Soluble Drug
نویسندگان
چکیده
Chlordiazepoxide, a member of the 1, 4-benzodiazepine, showing poor aqueous solubility and dissolution rate in water, so the present work was focused to prepare the microspheres of Chlordiazepoxide to improve its solubility and dissolution; using chitosan with different drug: polymer ratio by spray-drying technique. The effect of different drug: polymer ratio on the solubility and dissolution of microspheres was investigated. The prepared microspheres were characterized by Fourier transform infrared spectroscopy, Differential scanning colorimetry, XRD, Scanning electron microscopy, drug loading and drug-release properties. Spray dried microspheres exhibited decreased crystalline characteristics, higher solubility and dissolution compared with the pure sample of Chlordiazepoxide. Hence this spray drying technique can be used for the formulation purpose of Chlordiazepoxide to increase solubility & dissolution of the drug.
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